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Selfthermophoretic nanomotor selfthermophoresis confers z@pf nanomotors motility to achieve enhanced deep tumor penetration and therapy. Selfthermophoretic nanomotor selfthermophoresis confers z@pf nanomotors motility to achieve enhanced deep tumor penetration and therapy. Nirdriven ros selfsupplying z@pf nanomotor with efficient lysosome escape and enhanced tumor penetration is successfully developed for synergistic tumor cdtptt. However, low intratumoral hydrogen peroxide level and complex biological barriers hinder the ability of nanomedicines to generate.

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